All cancer treatments, such as radiotherapy and chemotherapy, have side effects. Loss of fertility is one of them. This means that you will no longer be able to get pregnant. It might be temporary, but sometimes it is permanent. Infertility can be very hard to come to terms with. The sense of loss can be strong for people of all ages.
Breast cancer treatments can significantly impact sex hormone levels, often inducing early menopause or menopausal-like symptoms associated with specific therapies, including:
Hormone Therapy: Medications that suppress or reduce hormone production.
Chemotherapy: Chemotherapeutic agents that may disrupt ovarian function
The likelihood of permanent menopause increases in women closer to the natural menopausal age, typically around 51 years globally, though studies specific to Nigerian women suggest a range of 48–52 years. In Nigerian women who have already undergone natural menopause, breast cancer treatments may still trigger infertility or menopausal-like symptoms. Predicting whether infertility will be temporary or permanent is challenging.
It is important to discuss your fertility with your doctor before starting your treatment. If you have a partner, they might want to join in during the discussion. That way you can both talk over your feelings and discuss your options.
It can be very difficult to learn that you might no longer be able to have children. Not everyone is sure if they want children. But having the choice taken away can be very difficult to cope with. It can be devastating if you wanted to have a child or more children. Some people are able to accept it and feel that coping with cancer is more important. Some patients seem to accept the news calmly when they start treatment, but they find it hits them later when the treatment is over.
Temporary or Permanent Infertility
During treatment, your periods may become irregular or cease if you have temporary infertility. However, after your treatment is over, they will return to normal. Younger women are more likely to experience this. You could still become pregnant, but it might take a few years for your periods to return to normal.
Find out from your healthcare team how long you should use contraception. Higher doses of chemotherapy increase the risk of permanent infertility. Additionally, older women who are approaching the age at which the menopause would naturally occur are more likely to experience it. Certain chemotherapy medications have the potential to harm your ovaries’ eggs. If this occurs, you will be unable to conceive and may experience menopausal symptoms.
Symptoms
Some of these symptoms could indicate induced infertility or an early menopause: period irregularities that end abruptly, hot flashes, dry skin, dry vagina, low energy, decreased interest in sex, mood swings, depression, poor sleep, issues with thinking, concentration, and memory (sometimes referred to as brain fog), joint and muscle pains, and the gradual weakening and thinning of bones (osteoporosis) as well as headaches and worsening migraines and urinary issues like incontinence, infection, or the need to urinate immediately.
Help with Symptoms
You can manage the effects of menopause with a variety of therapies and activities. Before you discover what works for you, you might need to try a few different approaches.
Your doctor may recommend an ointment or cream for you if sex is uncomfortable due to a dry vagina. Another option is to moisten your vagina with a lubricant. These are available without a prescription from your chemist. Different types of lubricants are available. Additionally, dilators are smooth, cone-shaped devices that stretch the vagina and change its sensation.
Possible options
There are other options you could consider if cancer has affected your fertility. These includes using donor eggs, using donated sperm so doctors can freeze embryos rather than eggs, using donated embryos or surrogacy (when another woman carries the baby for you) and adoption. You can have a small operation to remove one of your ovaries, which is then frozen. This is called ovarian tissue cryopreservation. The tissue is put back once your cancer treatment has finished. If the ovary then starts working, it may produce eggs and so you remain fertile.
For ovarian suppression, your doctor may suggest an injection, a hormone drug that stops the ovaries from working and makes a woman go into the menopause for a short time. Starting the hormone drug at least a week before chemotherapy starts, and have it every 3 to 4 weeks, It may protect your ovaries from the harmful effects of chemotherapy and help preserve your fertility.
These are difficult decisions and some options may not be straightforward. For example, some of them aren’t always cheap or funded by the health agencies . There is also a shortage of donors.
Possible Risks
Ovarian stimulation is not suitable for everyone. It takes at least 2 weeks to stimulate the ovaries. If you need to start chemotherapy straight away, there may not be time for you to have it. The drugs you have to stimulate the ovaries increase the levels of the hormone oestrogen. Oestrogen may encourage some cancers to grow, such as breast cancer or more rapidly. You might experience menopausal symptoms such as hot flushes. This treatment is not suitable for everyone and is not always successful.
Pregnancy after Treatment
Most doctors will advise you to wait for some time after treatment before becoming pregnant. The amount of time could depend on your type of cancer, the type of chemotherapy you have, the dose of chemotherapy you have, any other treatments you need or when it is safe to try.
Lastly, Healthcare providers in Nigeria should consider culturally sensitive counseling and tailored interventions to address these symptoms, taking into account local healthcare infrastructure and resource availability. Further research is needed to better understand the prevalence and management of treatment-induced menopausal symptoms among Nigerian women with breast cancer.
References
Cancer Research UK – /about-cancer/coping/physically/sex/women/losing-fertility
Accessed 13th July, 2025
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